Cerebral Invasion Mac OS

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Cerebral Invasion Mac OS

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This is a list of common misconceptions.Each entry is worded as a correction; the misconceptions themselves are implied rather than stated. These entries are concise summaries of the main subject articles, which can be consulted for more detail. Human African trypanosomiasis or sleeping sickness is a vector-borne parasitic disease that has a major impact on human health and welfare in sub-Saharan countries. Based mostly on data from animal models, it is currently thought that trypanosome entry into the brain occurs by initial infection of the choroid plexus and the circumventricular organs followed days to weeks later by entry into.

Senior Honors Projects, 2010-2019

Title

Author

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Date of Graduation

Spring 2016

Document Type

Thesis

Degree Name

Bachelor of Science (BS)

Department

Department of Biology

Advisor(s)

Chris Lantz

Abstract

Malaria is a life-threatening mosquito-borne disease caused by parasites of the genus Plasmodium, with about 200 million new cases reported each year. In rodent models of malaria, a variety of immune proteins called cytokines have been noted to either promote or suppress protective immunity. While the cytokine interleukin-3 (IL-3) clearly promotes host defense against some intestinal nematode parasites, few studies have reported a similar function for IL-3 in the pathophysiology of malaria. In this study, we investigated the role of IL-3 in a mouse model of cerebral malaria caused by Plasmodium berghei ANKA. We infected wild-type (WT) and IL-3 deficient (IL-3 KO) mice with P. berghei ANKA and characterized parameters indicative of a protective host response to infection. We found that male IL-3 KO mice generally survived longer than corresponding WT mice, although no differences between blood parasitemia or hematocrit levels were observed between the two genotypes. In addition, male IL-3 KO mice had an increased splenomegaly, and at day 6 p.i. showed less vascular damage in the brain than did corresponding infected WT mice. These findings suggest that IL-3 plays a role in suppressing protective immunity in a mouse model of cerebral malaria.

Recommended Citation

Perry, Brendon R., 'Role of interleukin-3 in an experimental model of mouse cerebral malaria caused by Plasmodium berghei ANKA' (2016). Senior Honors Projects, 2010-2019. 141.
https://commons.lib.jmu.edu/honors201019/141

Included in

Animal Diseases Commons, Immune System Diseases Commons, Parasitic Diseases Commons, Pathological Conditions, Signs and Symptoms Commons

COinS

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Case Report Posters

Title

Creator

Faculty Advisor(s)

Michael Fillyaw

Files

Description

795,000 people experience a stroke yearly, making it the leading cause of long-term disability, costing $34 billion. Strokes affecting the middle cerebral artery (MCA) cause impairments of strength, sensation, coordination, and balance of the contralateral side. Recovery from stroke is affected by premorbid status. Cardiovascular disease causes a majority of strokes. The purpose of this case report is to describe a progressive PT plan of care for a patient following MCA stroke with multiple comorbidities in the skilled nursing setting.

Publication Date

12-4-2016

Disciplines

Physical Therapy

Related Materials

The case report paper for this poster can be found here:

Preferred Citation

Lewis, Darien, 'Functional Training In A Patient With Middle Cerebral Artery Stroke With Multiple Comorbidities: A Case Report' (2016). Case Report Posters. Poster 87.
https://dune.une.edu/pt_studcrposter/87

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